Braintropic Powder DM235 / Sunifiram A Novel Nootropic Raw Powder Cas 314728-85-3

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Description

Sunifiram

1-benzoyl-4-propanoylpiperazine

What is Sunifiram?

Sunifiram is a nootropic research chemical derived from piracetam being researched as an enhancer of learning and memory by affecting the glutamatergic AMPA and NMDA receptors. It has not been through toxicological testing for use by humans and is strictly a research chemical although it is well tolerated in animal studies.

Sunifiram (developmental code name DM-235) is an experimental drug which has antiamnesic effects in animal studies and with significantly higher potency than piracetam.^[1] Sunifiram is a molecular simplification of unifiram (DM-232).^[2]Another analogue is sapunifiram (MN-19).^[3] As of 2016, sunifiram had not been subjected to toxicology testing, nor to any human clinical trials, and is not approved for use anywhere in the world

Our Sunifiram Powder

When you buy Sunifiram from limitlesslifenootropics.com, you get the highest purity raw powder properly packaged in ultraviolet light resistant scientific bottles, perfect for your research needs.

Sunifiram Overview

Sunifiram (also known as DM-235) is an ampakine research chemical which is an analogue of piracetam yet purported to be four times stronger in its nootropic effects. It is similar to racetams but has a different molecular structure. Sunifiram produces memory-enhancing effects at doses 4 times lower than piracetam. In animal studies, it attenuates amnestic effects produced by scopolamine, diphenhydramine, clonidine, and baclofen, suggesting a strong ability to improve memory by affecting glutamatergic and cholinergic neurotransmission. It is comparable to top nootropics like aniracetam and noopept in its anti-amnestic effects. It is being studied for Alzheimer’s disease and other cognitive deficits.

It has produced excitement among researchers because it appears to produce powerful memory-enhancing effects at lower doses than that of other nootropics like pramiracetam.

Sunifiram affects the hippocampus which is involved in learning and memory by producing long-term potentiation, an effect which increases the strength of synapses and translates into improved focus and memory.

Pharmacology

The mechanism of action of sunifiram is unknown.^[4] Sunifiram, as well as unifiram, were assayed at a wide panel of sites, including the most important receptors, ion channels, and transporters, but showed no affinity for any of the sites.^[4][3]They specifically did not bind to the glutamate, GABA, serotonin, dopamine, adrenergic, histamine, acetylcholine, oropioid receptors at concentrations of up to 1 μM.^[4][3] In addition, the drugs were tested on recombinant AMPA receptorsand showed no potentiation of the receptors, indicating that they do not act as AMPA receptor positive allosteric modulators.^[4] However, they were able to prevent the amnesia induced by the AMPA receptor antagonist NBQX in the passive avoidance test, suggesting that indirect/downstream AMPA receptor activation may be involved in their memory-enhancing effects.^[3]

Sunifiram, as well as other nootropics such as piracetam, levetiracetam, and aniracetam are able to antagonize inhibition of glucose transport by barbiturates (e.g., pentobarbital), diazepam, and certain other drugs in human erythrocytes in vitro (K_i = 26.0 uM for sunifiram), and this action has been found to correlate with their potency in reversingscopolamine-induced memory deficits in mice.^[3] However, this action has been regarded as very unlikely to represent the main mechanism of action of sunifiram

This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to out terms and conditions prior to purchase.

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